MolNFT v1 · #21668 · protein
Small heat shock protein from methanococcus jannaschii
1SHS: “Small heat shock protein from methanococcus jannaschii”. X-ray diffraction, 12 pockets (best druggability 0.54). MolNFT v1 #21668 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1SHS
- Type
- protein
- Length
- 920 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small heat shock protein
- UniProt
- Q57733
- Pockets
- 12 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Small heat shock protein | protein | 115 | 8% helix, 50% strand | Q57733 |
Pockets
12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.54 | 0.80 | 32 | empty |
| 2 | 177 | 0.53 | 0.79 | 24 | empty |
| 3 | 183 | 0.53 | 0.79 | 24 | empty |
| 4 | 177 | 0.53 | 0.79 | 26 | empty |
| 5 | 166 | 0.52 | 0.79 | 23 | empty |
Interfaces
13 interfaces between chains.
- B–D · 1769 Ų buried · 38 hydrogen bonds · protein-protein
- G–H · 1761 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 1757 Ų buried · 33 hydrogen bonds · protein-protein
- C–G · 758 Ų buried · 10 hydrogen bonds · protein-protein
- A–E · 750 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q57733
- Elsewhere: RCSB PDB 1SHS · PDBe 1SHS · UniProt Q57733
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