Research workbench
Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to the dead-end complex xanthine and pyrophosphate
Analyse Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8FWY
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.54
- Source
- Trypanosoma cruzi (strain CL Brener)
- Molecule
- Hypoxanthine-guanine phosphoribosyltransferase
- EC
- 2.4.2.8
- UniProt
- A0A7J6XZA2
- Ligands
- XAN, PO4
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · resolution 1.54 · 2 distinct chains · 24% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) | protein | 217 | 24% helix, 35% strand | A0A7J6XZA2 |
| B | Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) | protein | 214 | 24% helix, 35% strand | A0A7J6XZA2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 431 | 0.64 | 0.78 | 37 | XAN, PO4 |
| 2 | 459 | 0.61 | 0.76 | 38 | XAN, PO4 |
| 3 | 119 | 0.54 | 0.82 | 28 | empty |
| 4 | 94 | 0.53 | 0.84 | 25 | empty |
| 5 | 94 | 0.39 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2024 Ų buried · 25 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A7J6XZA2
- Elsewhere: RCSB PDB 8FWY · PDBe 8FWY · UniProt A0A7J6XZA2
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