Research workbench
Human GAR transformylase in complex with GAR substrate and AGF320 inhibitor
Analyse Human GAR transformylase in complex with GAR substrate and AGF320 inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8FJX
- Type
- protein
- Length
- 200 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.17
- Source
- Homo sapiens
- Molecule
- Trifunctional purine biosynthetic protein adenosine-3
- EC
- 6.3.4.13, 6.3.3.1, 2.1.2.2
- UniProt
- P22102
- Ligands
- Y7L, GAR
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · resolution 2.17 · 1 distinct chain · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trifunctional purine biosynthetic protein adenosine-3 (EC 6.3.4.13, 6.3.3.1, 2.1.2.2) | protein | 200 | 37% helix, 24% strand | P22102 |
Ligands and binding sites
- Y7L · N-{5-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]thiophene-2-carbonyl}-L-glutamic acid · ligand · chains A
- GAR · Glycinamide ribonucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 316 | 0.64 | 0.80 | 37 | Y7L, GAR |
Compared structures
- P22102 · AlphaFold monomer V2.0 prediction for trifunctional purine biosynthetic protein… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22102
- Elsewhere: RCSB PDB 8FJX · PDBe 8FJX · UniProt P22102
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