Research workbench

UBE3A isoform 2 AZUL domain

Analyse UBE3A isoform 2 AZUL domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8EPT
Type: protein
Length: 90 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Homo sapiens
Molecule: Ubiquitin-protein ligase E3A
EC: 2.3.2.26
UniProt: Q05086
Ligands: ZN
Pockets: 1 · best druggability 0.51

Structure

solution nmr · resolution NOT · 1 distinct chain · 39% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-protein ligase E3A (EC 2.3.2.26)	protein	90	39% helix, 0% strand	Q05086

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	199	0.51	0.77	28	empty

Compared structures

Q05086 · AlphaFold monomer V2.0 prediction for ubiquitin-protein ligase E3A (Q05086) · a predicted model of the same protein · chain A against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05086
Elsewhere: RCSB PDB 8EPT · PDBe 8EPT · UniProt Q05086

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