Research workbench
CryoEM structure of nucleotide-free GroEL-Rubisco.
Analyse CryoEM structure of nucleotide-free GroEL-Rubisco. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8BA7
- Type
- protein
- Length
- 7,336 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 4.4
- Source
- Escherichia coli
- Molecule
- Chaperonin GroEL
- EC
- 5.6.1.7
- UniProt
- P0A6F5
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · resolution 4.4 · 1 distinct chain · 53% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N | Chaperonin GroEL (EC 5.6.1.7) | protein | 524 | 53% helix, 17% strand | P0A6F5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1020 | 0.78 | 0.80 | 104 | empty |
| 2 | 908 | 0.78 | 0.80 | 97 | empty |
| 3 | 997 | 0.77 | 0.79 | 102 | empty |
| 4 | 859 | 0.77 | 0.80 | 87 | empty |
| 5 | 1105 | 0.76 | 0.79 | 113 | empty |
Interfaces
28 interfaces between chains.
- H–N · 1588 Ų buried · 18 hydrogen bonds · protein-protein
- E–F · 1586 Ų buried · 19 hydrogen bonds · protein-protein
- L–M · 1577 Ų buried · 19 hydrogen bonds · protein-protein
- M–N · 1572 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 1566 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- P0A6F5 · AlphaFold monomer V2.0 prediction for 60 kda chaperonin (P0A6F5) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6F5
- Elsewhere: RCSB PDB 8BA7 · PDBe 8BA7 · UniProt P0A6F5
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