Research workbench
Amyloid fibril (in vitro) from full-length hnRNPA1 protein
Analyse Amyloid fibril (in vitro) from full-length hnRNPA1 protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7ZJ2
- Type
- protein
- Length
- 540 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.32
- Source
- Homo sapiens
- Molecule
- Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1
- UniProt
- P09651
- Pockets
- 2 · best druggability 0.50
Structure
electron microscopy · resolution 3.32 · 1 distinct chain · 0% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1 | protein | 45 | 0% helix, 18% strand | P09651 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.50 | 0.76 | 35 | empty |
| 2 | 211 | 0.47 | 0.74 | 33 | empty |
Interfaces
38 interfaces between chains.
- C–E · 1803 Ų buried · 59 hydrogen bonds · protein-protein
- I–K · 1801 Ų buried · 59 hydrogen bonds · protein-protein
- E–G · 1799 Ų buried · 59 hydrogen bonds · protein-protein
- B–D · 1799 Ų buried · 59 hydrogen bonds · protein-protein
- A–C · 1797 Ų buried · 59 hydrogen bonds · protein-protein
Compared structures
- P09651 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein A1 (P09651) · a predicted model of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09651
- Elsewhere: RCSB PDB 7ZJ2 · PDBe 7ZJ2 · UniProt P09651
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