Research workbench
Crystal structure of ZYG11B bound to AFLH degron
Analyse Crystal structure of ZYG11B bound to AFLH degron in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7XYW
- Type
- protein
- Length
- 489 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.5
- Source
- Homo sapiens
- Molecule
- Protein zyg-11 homolog B
- UniProt
- Q9C0D3
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · resolution 2.5 · 2 distinct chains · 72% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Protein zyg-11 homolog B | protein | 245 | 71% helix, 1% strand | Q9C0D3 |
| A | Protein zyg-11 homolog B | protein | 244 | 72% helix, 1% strand | Q9C0D3 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.53 | 0.77 | 26 | empty |
| 2 | 87 | 0.38 | 0.77 | 21 | empty |
| 3 | 61 | 0.36 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- B–A · 1495 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- Q9C0D3 · AlphaFold monomer V2.0 prediction for protein zyg-11 homolog B (Q9C0D3) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C0D3
- Elsewhere: RCSB PDB 7XYW · PDBe 7XYW · UniProt Q9C0D3
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