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Crystal structure of TrkA (G595R) kinase domain
Analyse Crystal structure of TrkA (G595R) kinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VKM
- Type
- protein
- Length
- 300 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.55
- Source
- Homo sapiens
- Molecule
- Tyrosine-protein kinase receptor
- EC
- 2.7.10.1
- UniProt
- J3KP20
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · resolution 2.55 · 1 distinct chain · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase receptor (EC 2.7.10.1) | protein | 300 | 39% helix, 17% strand | J3KP20 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 422 | 0.65 | 0.78 | 40 | empty |
| 2 | 118 | 0.65 | 0.88 | 21 | empty |
| 3 | 67 | 0.31 | 0.74 | 15 | empty |
Compared structures
- 7VKM · Crystal structure of trka (G595R) kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt J3KP20
- Elsewhere: RCSB PDB 7VKM · PDBe 7VKM · UniProt J3KP20
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