Research workbench
Structure of dimeric uPAR at low pH
Analyse Structure of dimeric uPAR at low pH in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V63
- Type
- protein
- Length
- 371 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.906
- Source
- Homo sapiens
- Molecule
- Urokinase plasminogen activator surface receptor
- UniProt
- Q03405
- Ligands
- NAG
- Pockets
- 3 · best druggability 0.37
Structure
x-ray diffraction · resolution 2.906 · 2 distinct chains · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Urokinase plasminogen activator surface receptor | protein | 181 | 6% helix, 50% strand | Q03405 |
| B | Urokinase plasminogen activator surface receptor | protein | 190 | 5% helix, 45% strand | Q03405 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.37 | 0.75 | 22 | empty |
| 2 | 78 | 0.31 | 0.73 | 22 | empty |
| 3 | 53 | 0.26 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 974 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03405
- Elsewhere: RCSB PDB 7V63 · PDBe 7V63 · UniProt Q03405
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.