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Type 1D alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient

Analyse Type 1D alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7V48
Type: protein
Length: 378 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.0
Source: Homo sapiens
Molecule: Alpha-synuclein
UniProt: P37840

Structure

electron microscopy · resolution 3.0 · 1 distinct chain · 0% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, E, C, F, D	Alpha-synuclein	protein	63	0% helix, 29% strand	P37840

Interfaces

9 interfaces between chains.

B–E · 2444 Å² buried · 67 hydrogen bonds · protein-protein
B–F · 2440 Å² buried · 66 hydrogen bonds · protein-protein
A–C · 2438 Å² buried · 64 hydrogen bonds · protein-protein
A–D · 2436 Å² buried · 65 hydrogen bonds · protein-protein
B–A · 75 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

7V48 · Type 1D alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal… · the same entry in another collection · chain C against C, TM-score 1.00
P37840 · AlphaFold monomer V2.0 prediction for alpha-synuclein (P37840) · a predicted model of the same protein · chain B against A, TM-score 0.21

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37840
Elsewhere: RCSB PDB 7V48 · PDBe 7V48 · UniProt P37840

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