Research workbench

Physachenolide C with Bromodomain (BRD3-BD1)

Analyse Physachenolide C with Bromodomain (BRD3-BD1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7R8R
Type: protein
Length: 114 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.8
Source: Homo sapiens
Molecule: Bromodomain-containing protein 3
UniProt: Q15059
Ligands: 8L6
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · resolution 1.8 · 1 distinct chain · 59% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromodomain-containing protein 3	protein	114	59% helix, 0% strand	Q15059

Ligands and binding sites

8L6 · Physachenolide C · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.52	0.82	18	8L6

Compared structures

Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15059
Elsewhere: RCSB PDB 7R8R · PDBe 7R8R · UniProt Q15059

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