Research workbench
Structure of recombinant human gamma-Tubulin Ring Complex (spokes 1-14, homogeneous dataset)
Analyse Structure of recombinant human gamma-Tubulin Ring Complex (spokes 1-14… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QJC
- Type
- protein
- Length
- 15,623 residues
- Chains
- 41
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 16.1
- Source
- Homo sapiens
- Molecule
- actin, cytoplasmic 1; Gamma-tubulin complex component 2; Gamma-tubulin complex component…
- UniProt
- A0A6I9HGD1, Q9BSJ2, Q96CW5, Q9UGJ1, Q96RT8, Q96RT7, P23258, Q08AG7
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · resolution 16.1 · 22 distinct chains · 60% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| e | actin, cytoplasmic 1 | protein | 364 | 42% helix, 16% strand | A0A6I9HGD1 |
| A | Gamma-tubulin complex component 2 | protein | 613 | 60% helix, 3% strand | Q9BSJ2 |
| B | Gamma-tubulin complex component 3 | protein | 610 | 63% helix, 2% strand | Q96CW5 |
| C | Gamma-tubulin complex component 2 | protein | 620 | 59% helix, 3% strand | Q9BSJ2 |
| D | Gamma-tubulin complex component 3 | protein | 581 | 65% helix, 2% strand | Q96CW5 |
| E | Gamma-tubulin complex component 2 | protein | 638 | 58% helix, 3% strand | Q9BSJ2 |
| F | Gamma-tubulin complex component 3 | protein | 599 | 64% helix, 2% strand | Q96CW5 |
| G | Gamma-tubulin complex component 2 | protein | 640 | 58% helix, 3% strand | Q9BSJ2 |
| H, N | Gamma-tubulin complex component 3 | protein | 594 | 64% helix, 2% strand | Q96CW5 |
| I | Gamma-tubulin complex component 4 | protein | 521 | 67% helix, 3% strand | Q9UGJ1 |
| J | Gamma-tubulin complex component 5 | protein | 534 | 65% helix, 0% strand | Q96RT8 |
| K | Gamma-tubulin complex component 4 | protein | 562 | 64% helix, 3% strand | Q9UGJ1 |
| L | Gamma-tubulin complex component 6 | protein | 566 | 58% helix, 0% strand | Q96RT7 |
| O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 | Tubulin gamma-1 chain | protein | 420 | 43% helix, 18% strand | P23258 |
| b, g, i, k, m | Mitotic-spindle organizing protein 1 | protein | 65 | 82% helix, 0% strand | Q08AG7 |
| a | Gamma-tubulin complex component 3 | protein | 116 | 49% helix, 0% strand | Q96CW5 |
| f, h | Gamma-tubulin complex component 3 | protein | 99 | 62% helix, 0% strand | Q96CW5 |
| j | Gamma-tubulin complex component 3 | protein | 107 | 56% helix, 0% strand | Q96CW5 |
| d | Mitotic-spindle organizing protein 1 | protein | 59 | 76% helix, 0% strand | Q08AG7 |
| c | Gamma-tubulin complex component 6 | protein | 158 | 55% helix, 0% strand | Q96RT7 |
| l | Gamma-tubulin complex component 5 | protein | 108 | 67% helix, 0% strand | Q96RT8 |
| M | Gamma-tubulin complex component 2 | protein | 636 | 58% helix, 3% strand | Q9BSJ2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1039 | 0.87 | 0.88 | 119 | empty |
| 2 | 1175 | 0.85 | 0.86 | 153 | empty |
| 3 | 830 | 0.84 | 0.86 | 99 | empty |
| 4 | 334 | 0.83 | 0.92 | 30 | empty |
| 5 | 405 | 0.82 | 0.90 | 58 | empty |
Interfaces
82 interfaces between chains.
- C–Q · 2724 Ų buried · 33 hydrogen bonds · protein-protein
- D–R · 2510 Ų buried · 21 hydrogen bonds · protein-protein
- B–P · 2497 Ų buried · 17 hydrogen bonds · protein-protein
- A–O · 2487 Ų buried · 22 hydrogen bonds · protein-protein
- 2–N · 2441 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- P23258 · AlphaFold monomer V2.0 prediction for tubulin gamma-1 chain (P23258) · a predicted model of the same protein · chain O against A, TM-score 0.96
- Q96RT8 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 5 (Q96RT8) · a predicted model of the same protein · chain J against A, TM-score 0.96
- Q96CW5 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 3 (Q96CW5) · a predicted model of the same protein · chain D against A, TM-score 0.95
- Q9BSJ2 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 2 (Q9BSJ2) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q08AG7 · AlphaFold monomer V2.0 prediction for mitotic-spindle organizing protein 1 (Q08AG7) · a predicted model of the same protein · chain b against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A6I9HGD1
- Every structure of UniProt Q9BSJ2
- Every structure of UniProt Q96CW5
- Every structure of UniProt Q9UGJ1
- Every structure of UniProt Q96RT8
- Every structure of UniProt Q96RT7
- Every structure of UniProt P23258
- Every structure of UniProt Q08AG7
- Elsewhere: RCSB PDB 7QJC · PDBe 7QJC · UniProt A0A6I9HGD1 · UniProt Q9BSJ2 · UniProt Q96CW5 · UniProt Q9UGJ1 · UniProt Q96RT8 · UniProt Q96RT7 · UniProt P23258 · UniProt Q08AG7
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