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Crystal Structure of SET/I2PP2A/TAF-1Beta core

Analyse Crystal Structure of SET/I2PP2A/TAF-1Beta core in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7MTO
Type: protein
Length: 188 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.791
Source: Homo sapiens
Molecule: Isoform 2 of Protein SET
UniProt: Q01105
Ligands: MG, CA
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · resolution 1.791 · 1 distinct chain · 47% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isoform 2 of Protein SET	protein	188	47% helix, 16% strand	Q01105

Ligands and binding sites

MG · Magnesium ion · metal · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	162	0.46	0.76	28	empty
2	93	0.35	0.74	18	empty

Compared structures

7MTO · Crystal structure of SET/I2PP2A/TAF-1BETA core · the same entry in another collection · chain A against A, TM-score 1.00
Q01105 · AlphaFold monomer V2.0 prediction for protein set (Q01105) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q01105
Elsewhere: RCSB PDB 7MTO · PDBe 7MTO · UniProt Q01105

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