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Crystal Structure of apo human FABP1 - orthorhombic form

Analyse Crystal Structure of apo human FABP1 - orthorhombic form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7FYA
Type: protein
Length: 259 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.88
Source: Homo sapiens
Molecule: Fatty acid-binding protein, liver
UniProt: P07148
Pockets: 5 · best druggability 0.84

Structure

x-ray diffraction · resolution 1.88 · 2 distinct chains · 12% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fatty acid-binding protein, liver	protein	129	12% helix, 59% strand	P07148
B	Fatty acid-binding protein, liver	protein	130	12% helix, 58% strand	P07148

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.84	0.96	37	empty
2	266	0.84	0.95	37	empty
3	56	0.54	0.89	27	empty
4	69	0.34	0.76	15	empty
5	61	0.33	0.77	22	empty

Interfaces

1 interface between chains.

A–B · 667 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

P07148 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, liver (P07148) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07148
Elsewhere: RCSB PDB 7FYA · PDBe 7FYA · UniProt P07148

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