Research workbench
Crystal structure of the Ctr9/Paf1/Cdc73/Rtf1 quaternary complex
Analyse Crystal structure of the Ctr9/Paf1/Cdc73/Rtf1 quaternary complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7DKH
- Type
- protein
- Length
- 3,343 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.9
- Source
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
- Molecule
- RNA polymerase-associated protein CTR9; RNA polymerase II-associated protein 1; Cell…
- UniProt
- P89105, P38351, Q06697, P53064
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · resolution 2.9 · 7 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | RNA polymerase-associated protein CTR9 | protein | 913 | 74% helix, 1% strand | P89105 |
| B, J | RNA polymerase II-associated protein 1 | protein | 99 | 32% helix, 2% strand | P38351 |
| C | Cell division control protein 73 | protein | 52 | 50% helix, 4% strand | Q06697 |
| D, H, L | RNA polymerase-associated protein RTF1 | protein | 51 | 65% helix, 0% strand | P53064 |
| F | RNA polymerase II-associated protein 1 | protein | 98 | 28% helix, 2% strand | P38351 |
| G, K | Cell division control protein 73 | protein | 51 | 49% helix, 4% strand | Q06697 |
| I | RNA polymerase-associated protein CTR9 | protein | 914 | 75% helix, 1% strand | P89105 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1200 | 0.80 | 0.82 | 103 | empty |
| 2 | 1021 | 0.80 | 0.81 | 102 | empty |
| 3 | 980 | 0.73 | 0.76 | 91 | empty |
| 4 | 1087 | 0.73 | 0.76 | 92 | empty |
| 5 | 740 | 0.72 | 0.78 | 80 | empty |
Interfaces
27 interfaces between chains.
- A–B · 6442 Ų buried · 87 hydrogen bonds · protein-protein
- I–J · 6363 Ų buried · 82 hydrogen bonds · protein-protein
- E–F · 6238 Ų buried · 76 hydrogen bonds · protein-protein
- E–G · 2418 Ų buried · 36 hydrogen bonds · protein-protein
- I–K · 2375 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 57 modified (engineered).
Compared structures
- 7DKH · Crystal structure of the CTR9/PAF1/CDC73/RTF1 quaternary complex · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P89105
- Every structure of UniProt P38351
- Every structure of UniProt Q06697
- Every structure of UniProt P53064
- Elsewhere: RCSB PDB 7DKH · PDBe 7DKH · UniProt P89105 · UniProt P38351 · UniProt Q06697 · UniProt P53064
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