Research workbench
Cryo-EM structure of human TLR3 in complex with UNC93B1
Analyse Cryo-EM structure of human TLR3 in complex with UNC93B1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7C76
- Type
- protein
- Length
- 1,174 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.4
- Source
- Homo sapiens
- Molecule
- Toll-like receptor 3; Protein unc-93 homolog B1
- UniProt
- O15455, Q9H1C4
- Ligands
- NAG, BMA
- Pockets
- 9 · best druggability 0.85
Structure
electron microscopy · resolution 3.4 · 2 distinct chains · 37% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Toll-like receptor 3 | protein | 691 | 13% helix, 16% strand | O15455 |
| B | Protein unc-93 homolog B1 | protein | 483 | 72% helix, 0% strand | Q9H1C4 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 23 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 860 | 0.85 | 0.86 | 84 | empty |
| 2 | 60 | 0.61 | 0.92 | 15 | empty |
| 3 | 82 | 0.56 | 0.86 | 23 | empty |
| 4 | 197 | 0.51 | 0.77 | 21 | empty |
| 5 | 66 | 0.48 | 0.83 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1471 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 glycan, 4 disulfide (N-glycosylation, disulfide).
Compared structures
- 7C76 · Cryo-EM structure of human TLR3 in complex with UNC93B1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H1C4 · AlphaFold monomer V2.0 prediction for protein unc-93 homolog B1 (Q9H1C4) · a predicted model of the same protein · chain B against A, TM-score 0.99
- O15455 · AlphaFold monomer V2.0 prediction for toll-like receptor 3 (O15455) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15455
- Every structure of UniProt Q9H1C4
- Elsewhere: RCSB PDB 7C76 · PDBe 7C76 · UniProt O15455 · UniProt Q9H1C4
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