Research workbench

bovine ATP synthase Stator domain, state 2

Analyse bovine ATP synthase Stator domain, state 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6ZIT
Type: protein
Length: 1,300 residues
Chains: 15
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.49
Source: Bos taurus
Molecule: ATP synthase protein 8; ATP synthase subunit a; ATP synthase subunit d, mitochondrial…
UniProt: P03929, P00847, P13620, Q00361, Q28851, Q28852, P14790, Q3ZBI7, P07926, P13619, P02721, P13621, P19483
Pockets: 20 · best druggability 0.78

Structure

electron microscopy · resolution 3.49 · 15 distinct chains · 69% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
8	ATP synthase protein 8	protein	38	61% helix, 0% strand	P03929
a	ATP synthase subunit a	protein	226	77% helix, 0% strand	P00847
d	ATP synthase subunit d, mitochondrial	protein	154	65% helix, 0% strand	P13620
e	ATP synthase subunit e, mitochondrial	protein	41	83% helix, 0% strand	Q00361
f	ATP synthase subunit f, mitochondrial	protein	83	64% helix, 1% strand	Q28851
g	ATP synthase subunit g, mitochondrial	protein	79	76% helix, 1% strand	Q28852
j	ATP synthase subunit ATP5MPL, mitochondrial	protein	48	79% helix, 0% strand	P14790
k	ATP synthase membrane subunit DAPIT, mitochondrial	protein	36	69% helix, 0% strand	Q3ZBI7
R	ATP synthase F(0) complex subunit C2, mitochondrial	protein	57	88% helix, 0% strand	P07926
K	ATP synthase F(0) complex subunit C2, mitochondrial	protein	58	83% helix, 0% strand	P07926
L	ATP synthase F(0) complex subunit C2, mitochondrial	protein	31	94% helix, 0% strand	P07926
b	ATP synthase F(0) complex subunit B1, mitochondrial	protein	209	84% helix, 2% strand	P13619
h	ATP synthase-coupling factor 6, mitochondrial	protein	62	55% helix, 0% strand	P02721
S	ATP synthase subunit O, mitochondrial	protein	89	43% helix, 28% strand	P13621
C	ATP synthase subunit alpha, mitochondrial	protein	89	12% helix, 39% strand	P19483

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	742	0.78	0.82	67	empty
2	420	0.77	0.86	40	empty
3	95	0.76	0.97	21	empty
4	423	0.75	0.84	54	empty
5	320	0.74	0.86	40	empty

Interfaces

30 interfaces between chains.

d–b · 3028 Å² buried · 22 hydrogen bonds · protein-protein
8–a · 1525 Å² buried · 10 hydrogen bonds · protein-protein
b–h · 1372 Å² buried · 15 hydrogen bonds · protein-protein
a–b · 1202 Å² buried · 11 hydrogen bonds · protein-protein
R–K · 1052 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (methylation).

Compared structures

6ZIT · Bovine ATP synthase stator domain, state 2 · the same entry in another collection · chain a against a, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03929
Every structure of UniProt P00847
Every structure of UniProt P13620
Every structure of UniProt Q00361
Every structure of UniProt Q28851
Every structure of UniProt Q28852
Every structure of UniProt P14790
Every structure of UniProt Q3ZBI7
Every structure of UniProt P07926
Every structure of UniProt P13619
Every structure of UniProt P02721
Every structure of UniProt P13621
Every structure of UniProt P19483
Elsewhere: RCSB PDB 6ZIT · PDBe 6ZIT · UniProt P03929 · UniProt P00847 · UniProt P13620 · UniProt Q00361 · UniProt Q28851 · UniProt Q28852 · UniProt P14790 · UniProt Q3ZBI7 · UniProt P07926 · UniProt P13619 · UniProt P02721 · UniProt P13621 · UniProt P19483

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