Research workbench
14-3-3 Sigma in complex with phosphorylated camkk2{pS511} peptide
Analyse 14-3-3 Sigma in complex with phosphorylated camkk2{pS511} peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Y8A
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.5
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- 14-3-3 protein sigma; Calcium/calmodulin-dependent protein kinase kinase 2
- EC
- 2.7.11.17
- UniProt
- P31947, Q96RR4
- Ligands
- MG, CL
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · resolution 1.5 · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein sigma | protein | 236 | 80% helix, 0% strand | P31947 |
| P | Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) | protein | 7 | 0% helix, 0% strand | Q96RR4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.56 | 0.81 | 23 | empty |
Interfaces
1 interface between chains.
- A–P · 522 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation, phosphorylation).
Compared structures
- 6Y8A · 14-3-3 sigma in complex with phosphorylated CAMKK2{PS511} peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q96RR4 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase kinase… · a predicted model of the same protein · chain P against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31947
- Every structure of UniProt Q96RR4
- Elsewhere: RCSB PDB 6Y8A · PDBe 6Y8A · UniProt P31947 · UniProt Q96RR4
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