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Crystal structure of SCLam E144S mutant, a non-specific endo-beta-1,3(4)-glucanase from family GH16, co-crystallized with laminarihexaose, presenting a laminaribiose and a glucose at active site
Analyse Crystal structure of SCLam E144S mutant, a non-specific… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XQM
- Type
- protein
- Length
- 263 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.85
- Source
- uncultured bacterium
- Molecule
- GH16 family protein
- EC
- 3.2.1.39
- UniProt
- A0A0B5H9B3
- Ligands
- GLC, BGC, CA, PO4
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · resolution 1.85 · 1 distinct chain · 4% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GH16 family protein (EC 3.2.1.39) | protein | 263 | 4% helix, 44% strand | A0A0B5H9B3 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- BGC · beta-D-glucopyranose · sugar · chains A
- CA · Calcium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 290 | 0.64 | 0.81 | 39 | GLC, BGC |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6XQM · Crystal structure of sclam E144S mutant, a non-specific endo-beta-1, 3(4)-glucanase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0B5H9B3
- Elsewhere: RCSB PDB 6XQM · PDBe 6XQM · UniProt A0A0B5H9B3
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