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Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MIP

Analyse Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6VA4
Type: RNA
Length: 21 nucleotides
Chains: 2
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Molecule: RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3'); RNA…
Ligands: QSY

Structure

solution nmr · resolution NOT · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA (5'-R(CPCPGPGPCPAPGPUPGPUP*G)-3')	rna	11	—	—
B	RNA (5'-R(CPAPCPAPCPGPUPCPGPG)-3')	rna	10	—	—

Ligands and binding sites

QSY · N-[3-(8-methoxy-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propyl]-N-methylcyclohexanaminium · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 547 Å² buried · 51 hydrogen bonds · nucleic-nucleic

Compared structures

6VA4 · Solution structure of the tau pre-mRNA exon 10 splicing regulatory element bound to mip · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6VA4 · PDBe 6VA4

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