Research workbench
EnvC bound to the FtsX periplasmic domain
Analyse EnvC bound to the FtsX periplasmic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TPI
- Type
- protein
- Length
- 578 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.1
- Source
- Escherichia coli (strain K12)
- Molecule
- Murein hydrolase activator EnvC; Cell division protein FtsX
- UniProt
- P37690, P0AC30
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · resolution 2.1 · 3 distinct chains · 52% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Murein hydrolase activator EnvC | protein | 380 | 59% helix, 17% strand | P37690 |
| B | Cell division protein FtsX | protein | 101 | 39% helix, 23% strand | P0AC30 |
| C | Cell division protein FtsX | protein | 97 | 37% helix, 24% strand | P0AC30 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 321 | 0.62 | 0.78 | 34 | empty |
| 2 | 209 | 0.49 | 0.75 | 22 | empty |
| 3 | 82 | 0.42 | 0.79 | 18 | empty |
| 4 | 78 | 0.38 | 0.77 | 19 | empty |
| 5 | 57 | 0.26 | 0.73 | 13 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1199 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 973 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6TPI · Envc bound to the ftsx periplasmic domain · the same entry in another collection · chain A against A, TM-score 1.00
- P37690 · AlphaFold monomer V2.0 prediction for murein hydrolase activator envc (P37690) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P0AC30 · AlphaFold monomer V2.0 prediction for cell division protein ftsx (P0AC30) · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37690
- Every structure of UniProt P0AC30
- Elsewhere: RCSB PDB 6TPI · PDBe 6TPI · UniProt P37690 · UniProt P0AC30
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