Research workbench
Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type 11 in complex with the phosphorylated immune receptor tyrosine-based switch motif
Analyse Structure of the N-SH2 domain of the human tyrosine-protein phosphatase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6ROZ
- Type
- protein
- Length
- 224 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.89
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- Tyrosine-protein phosphatase non-receptor type 11; immune receptor tyrosine-based switch…
- EC
- 3.1.3.48
- UniProt
- Q06124
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · resolution 2.89 · 2 distinct chains · 21% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) | protein | 102 | 24% helix, 29% strand | Q06124 |
| B, D | immune receptor tyrosine-based switch motif (ITSM) | protein | 10 | 0% helix, 30% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.43 | 0.79 | 16 | empty |
| 2 | 61 | 0.32 | 0.76 | 16 | empty |
Interfaces
3 interfaces between chains.
- C–D · 652 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 631 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 274 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 6ROZ · Structure of the N-SH2 domain of the human tyrosine-protein phosphatase non-receptor type… · the same entry in another collection · chain A against A, TM-score 1.00
- Q06124 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 11… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06124
- Elsewhere: RCSB PDB 6ROZ · PDBe 6ROZ · UniProt Q06124
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.