Research workbench
Crystal structure of Trypanosoma cruzi bromodomain BDF2 (TcCLB.506553.20)
Analyse Crystal structure of Trypanosoma cruzi bromodomain BDF2 (TcCLB.506553.20) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NP7
- Type
- protein
- Length
- 226 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.16
- Source
- Trypanosoma cruzi
- Molecule
- Bromodomain factor 2 protein
- UniProt
- A0A2V2V5V1
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · resolution 2.16 · 1 distinct chain · 57% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bromodomain factor 2 protein | protein | 113 | 57% helix, 0% strand | A0A2V2V5V1 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 588 | 0.72 | 0.80 | 58 | empty |
| 2 | 118 | 0.50 | 0.80 | 21 | empty |
| 3 | 76 | 0.47 | 0.82 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 610 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6NP7 · Crystal structure of trypanosoma cruzi bromodomain BDF2 (TCCLB.506553.20) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2V2V5V1
- Elsewhere: RCSB PDB 6NP7 · PDBe 6NP7 · UniProt A0A2V2V5V1
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