MolNFT v1 · #158280 · protein
Crystal structure of trypanosoma cruzi bromodomain BDF2 (TCCLB.506553.20)
6NP7 · Bromodomain factor 2 protein: “Crystal structure of trypanosoma cruzi bromodomain BDF2 (TCCLB.506553.20)”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #158280 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6NP7
- Type
- protein
- Length
- 226 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain factor 2 protein
- UniProt
- A0A2V2V5V1
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 57% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Bromodomain factor 2 protein | protein | 113 | 57% helix, 0% strand | A0A2V2V5V1 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 588 | 0.72 | 0.80 | 58 | empty |
| 2 | 118 | 0.50 | 0.80 | 21 | empty |
| 3 | 76 | 0.47 | 0.82 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 610 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 6NP7 · Crystal structure of Trypanosoma cruzi bromodomain BDF2 (TcCLB.506553.20) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2V2V5V1
- Elsewhere: RCSB PDB 6NP7 · PDBe 6NP7 · UniProt A0A2V2V5V1
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