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Hsp90-beta bound to PU-11-trans

Analyse Hsp90-beta bound to PU-11-trans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6N8Y
Type: protein
Length: 210 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.55391
Source: Homo sapiens
Molecule: Heat shock protein HSP 90-beta
UniProt: P08238
Ligands: KFY
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · resolution 1.55391 · 1 distinct chain · 45% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock protein HSP 90-beta	protein	210	45% helix, 22% strand	P08238

Ligands and binding sites

KFY · 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl) methyl]-9H-purin-6-amine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	360	0.71	0.83	43	KFY

Compared structures

6N8Y · HSP90-beta bound to pu-11-trans · the same entry in another collection · chain A against A, TM-score 1.00
P08238 · AlphaFold monomer V2.0 prediction for heat shock protein HSP 90-beta (P08238) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08238
Elsewhere: RCSB PDB 6N8Y · PDBe 6N8Y · UniProt P08238

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