Research workbench
Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622
Analyse Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N33
- Type
- protein
- Length
- 292 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.25
- Source
- Homo sapiens
- Molecule
- Macrophage colony-stimulating factor 1 receptor
- EC
- 2.7.10.1
- UniProt
- P07333
- Ligands
- 622
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · resolution 2.25 · 1 distinct chain · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage colony-stimulating factor 1 receptor (EC 2.7.10.1) | protein | 292 | 43% helix, 19% strand | P07333 |
Ligands and binding sites
- 622 · 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl) methyl]pyridin-2-amine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 654 | 0.72 | 0.79 | 75 | 622 |
Compared structures
- 6N33 · Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622 · the same entry in another collection · chain A against A, TM-score 1.00
- P07333 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 receptor… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07333
- Elsewhere: RCSB PDB 6N33 · PDBe 6N33 · UniProt P07333
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