Research workbench
Structure of the Bovine p85a BH domain R228E mutant
Analyse Structure of the Bovine p85a BH domain R228E mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MRP
- Type
- protein
- Length
- 361 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.403
- Source
- Bos taurus
- Molecule
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- UniProt
- P23727
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · resolution 2.403 · 2 distinct chains · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 179 | 64% helix, 0% strand | P23727 |
| A | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 182 | 62% helix, 0% strand | P23727 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.48 | 0.77 | 25 | empty |
| 2 | 66 | 0.41 | 0.80 | 12 | empty |
| 3 | 67 | 0.33 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- B–A · 387 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 6MRP · Structure of the bovine P85A bh domain R228E mutant · the same entry in another collection · chain A against A, TM-score 1.00
- P23727 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase regulatory subunit… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23727
- Elsewhere: RCSB PDB 6MRP · PDBe 6MRP · UniProt P23727
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