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Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) D11A mutant from Salmonella typhimurium complexed with histidine

Analyse Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6MKW
Type: protein
Length: 237 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.32
Source: Salmonella typhimurium (strain 14028s / SGSC 2262)
Molecule: Lysine/arginine/ornithine transport protein
UniProt: A0A0F6B499
Ligands: HIS
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · resolution 2.32 · 1 distinct chain · 38% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lysine/arginine/ornithine transport protein	protein	237	38% helix, 24% strand	A0A0F6B499

Ligands and binding sites

HIS · Histidine · ligand · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.36	0.75	17	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6MKW · Crystal structure of the periplasmic lysine-, arginine-, ornithine- binding protein (lao)… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt A0A0F6B499
Elsewhere: RCSB PDB 6MKW · PDBe 6MKW · UniProt A0A0F6B499

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