Research workbench
Substrate Free Cytochrome P450 3A5 (CYP3A5)
Analyse Substrate Free Cytochrome P450 3A5 (CYP3A5) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MJM
- Type
- protein
- Length
- 453 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Homo sapiens
- Molecule
- Cytochrome P450 3A5
- EC
- 1.14.14.1
- UniProt
- P20815
- Ligands
- HEM
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · resolution 2.2 · 1 distinct chain · 52% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450 3A5 (EC 1.14.14.1) | protein | 453 | 52% helix, 9% strand | P20815 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1177 | 0.86 | 0.86 | 91 | HEM, GOL |
| 2 | 173 | 0.59 | 0.82 | 25 | empty |
| 3 | 200 | 0.47 | 0.74 | 32 | empty |
| 4 | 151 | 0.45 | 0.75 | 24 | empty |
| 5 | 53 | 0.25 | 0.73 | 21 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20815
- Elsewhere: RCSB PDB 6MJM · PDBe 6MJM · UniProt P20815
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.