Research workbench
Structure of human CYP11B1 in complex with fadrozole
Analyse Structure of human CYP11B1 in complex with fadrozole in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6M7X
- Type
- protein
- Length
- 924 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.095
- Source
- Homo sapiens
- Molecule
- Cytochrome P450 11B1, mitochondrial
- EC
- 1.14.15.4
- UniProt
- P15538
- Ligands
- JD7, HEM
- Pockets
- 9 · best druggability 0.86
Structure
x-ray diffraction · resolution 2.095 · 2 distinct chains · 56% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450 11B1, mitochondrial (EC 1.14.15.4) | protein | 463 | 56% helix, 11% strand | P15538 |
| B | Cytochrome P450 11B1, mitochondrial (EC 1.14.15.4) | protein | 461 | 57% helix, 11% strand | P15538 |
Ligands and binding sites
- JD7 · 4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile · ligand · 2 copies · chains A, B
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 927 | 0.86 | 0.87 | 73 | JD7, HEM |
| 2 | 883 | 0.85 | 0.87 | 75 | JD7, HEM |
| 3 | 1137 | 0.74 | 0.77 | 91 | empty |
| 4 | 122 | 0.39 | 0.74 | 25 | empty |
| 5 | 120 | 0.39 | 0.74 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 427 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15538
- Elsewhere: RCSB PDB 6M7X · PDBe 6M7X · UniProt P15538
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.