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structure of human bile salt exporter ABCB11

Analyse structure of human bile salt exporter ABCB11 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LR0
Type: protein
Length: 1,230 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.5
Source: Homo sapiens
Molecule: Bile salt export pump
EC: 7.6.2.-
UniProt: O95342
Pockets: 15 · best druggability 0.85

Structure

electron microscopy · resolution 3.5 · 1 distinct chain · 27% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
U	Bile salt export pump (EC 7.6.2.-)	protein	1230	27% helix, 4% strand	O95342

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	821	0.85	0.87	79	empty
2	125	0.76	0.95	33	empty
3	162	0.62	0.84	25	empty
4	98	0.62	0.88	19	empty
5	53	0.59	0.91	20	empty

Compared structures

6LR0 · Structure of human bile salt exporter ABCB11 · the same entry in another collection · chain U against U, TM-score 1.00
O95342 · AlphaFold monomer V2.0 prediction for bile salt export pump (O95342) · a predicted model of the same protein · chain U against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95342
Elsewhere: RCSB PDB 6LR0 · PDBe 6LR0 · UniProt O95342

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