Research workbench
crystal structure of alpha-momorcharin in complex with cAMP
Analyse crystal structure of alpha-momorcharin in complex with cAMP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LOQ
- Type
- protein
- Length
- 246 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.331
- Source
- Momordica charantia
- Molecule
- Ribosome-inactivating protein momordin I
- EC
- 3.2.2.22
- UniProt
- P16094
- Ligands
- CMP
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · resolution 1.331 · 1 distinct chain · 42% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosome-inactivating protein momordin I (EC 3.2.2.22) | protein | 246 | 42% helix, 25% strand | P16094 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.49 | 0.79 | 20 | CMP |
| 2 | 100 | 0.41 | 0.77 | 16 | empty |
Compared structures
- 6LOQ · Crystal structure of alpha-momorcharin in complex with camp · the same entry in another collection · chain A against A, TM-score 1.00
- P16094 · AlphaFold monomer V2.0 prediction for ribosome-inactivating protein momordin I (P16094) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16094
- Elsewhere: RCSB PDB 6LOQ · PDBe 6LOQ · UniProt P16094
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