Research workbench
Crystal structure of CASK-CaMK in complex with Mint1-CID
Analyse Crystal structure of CASK-CaMK in complex with Mint1-CID in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6LNM
- Type
- protein
- Length
- 1,096 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.4
- Source
- Mus musculus; Rattus norvegicus
- Molecule
- Peripheral plasma membrane protein CASK; Amyloid-beta A4 precursor protein-binding family…
- EC
- 2.7.11.1
- UniProt
- Q62915, B2RUJ5
- Pockets
- 12 · best druggability 0.69
Structure
x-ray diffraction · resolution 2.4 · 4 distinct chains · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peripheral plasma membrane protein CASK (EC 2.7.11.1) | protein | 325 | 42% helix, 17% strand | Q62915 |
| B, D | Amyloid-beta A4 precursor protein-binding family A member 1 | protein | 42 | 48% helix, 7% strand | B2RUJ5 |
| C, E | Peripheral plasma membrane protein CASK (EC 2.7.11.1) | protein | 322 | 43% helix, 16% strand | Q62915 |
| F | Amyloid-beta A4 precursor protein-binding family A member 1 | protein | 43 | 47% helix, 2% strand | B2RUJ5 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 604 | 0.69 | 0.78 | 59 | empty |
| 2 | 576 | 0.65 | 0.76 | 62 | empty |
| 3 | 439 | 0.63 | 0.77 | 59 | empty |
| 4 | 449 | 0.62 | 0.76 | 50 | empty |
| 5 | 329 | 0.55 | 0.75 | 33 | empty |
Interfaces
7 interfaces between chains.
- E–F · 1611 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1604 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1563 Ų buried · 17 hydrogen bonds · protein-protein
- A–E · 424 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 349 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6LNM · Crystal structure of cask-camk in complex with MINT1-cid · the same entry in another collection · chain F against F, TM-score 1.00
- Q62915 · AlphaFold monomer V2.0 prediction for peripheral plasma membrane protein cask (Q62915) · a predicted model of the same protein · chain E against A, TM-score 0.92
- B2RUJ5 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 precursor protein-binding family a… · a predicted model of the same protein · chain B against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62915
- Every structure of UniProt B2RUJ5
- Elsewhere: RCSB PDB 6LNM · PDBe 6LNM · UniProt Q62915 · UniProt B2RUJ5
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