MolNFT v1 · #155931 · protein
Crystal structure of cask-camk in complex with MINT1-cid
6LNM · Peripheral plasma membrane protein cask: “Crystal structure of cask-camk in complex with MINT1-cid”. X-ray diffraction, 12 pockets (best druggability 0.69). MolNFT v1 #155931 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6LNM
- Type
- protein
- Length
- 1,096 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peripheral plasma membrane protein cask; Amyloid-beta A4 precursor protein-binding family…
- EC
- 2.7.11.1
- UniProt
- Q62915, B2RUJ5
- Pockets
- 12 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peripheral plasma membrane protein cask (EC 2.7.11.1) | protein | 325 | 42% helix, 17% strand | Q62915 |
| B, D | Amyloid-beta A4 precursor protein-binding family a member 1 | protein | 42 | 48% helix, 7% strand | B2RUJ5 |
| C, E | Peripheral plasma membrane protein cask (EC 2.7.11.1) | protein | 322 | 43% helix, 16% strand | Q62915 |
| F | Amyloid-beta A4 precursor protein-binding family a member 1 | protein | 43 | 47% helix, 2% strand | B2RUJ5 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 604 | 0.69 | 0.78 | 59 | empty |
| 2 | 576 | 0.65 | 0.76 | 62 | empty |
| 3 | 439 | 0.63 | 0.77 | 59 | empty |
| 4 | 449 | 0.62 | 0.76 | 50 | empty |
| 5 | 329 | 0.55 | 0.75 | 33 | empty |
Interfaces
7 interfaces between chains.
- E–F · 1611 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1604 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1563 Ų buried · 17 hydrogen bonds · protein-protein
- A–E · 424 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 349 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6LNM · Crystal structure of CASK-CaMK in complex with Mint1-CID · the same entry in another collection · chain F against F, TM-score 1.00
- Q62915 · AlphaFold monomer V2.0 prediction for peripheral plasma membrane protein cask (Q62915) · a predicted model of the same protein · chain E against A, TM-score 0.92
- B2RUJ5 · AlphaFold monomer V2.0 prediction for amyloid-beta A4 precursor protein-binding family a… · a predicted model of the same protein · chain B against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62915
- Every structure of UniProt B2RUJ5
- Elsewhere: RCSB PDB 6LNM · PDBe 6LNM · UniProt Q62915 · UniProt B2RUJ5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.