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Crystal structure of human Dishevelled1 PDZ domain with its inhibitor NPL3009

Analyse Crystal structure of human Dishevelled1 PDZ domain with its inhibitor NPL3009 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6LCB
Type: protein
Length: 82 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.4
Source: Homo sapiens
Molecule: Segment polarity protein dishevelled homolog DVL-1
UniProt: O14640
Ligands: E83, SO4

Structure

x-ray diffraction · resolution 1.4 · 1 distinct chain · 22% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Segment polarity protein dishevelled homolog DVL-1	protein	82	22% helix, 33% strand	O14640

Ligands and binding sites

E83 · 2-[[3-[(2E)-2-[1,3-bis(oxidanylidene)-1-phenyl-butan-2-ylidene]hydrazinyl]phenyl]sulfonylamino]benzoic acid · ligand · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6LCB · Crystal structure of human DISHEVELLED1 PDZ domain with its inhibitor NPL3009 · the same entry in another collection · chain A against A, TM-score 1.00
O14640 · AlphaFold monomer V2.0 prediction for segment polarity protein dishevelled homolog dvl-1… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14640
Elsewhere: RCSB PDB 6LCB · PDBe 6LCB · UniProt O14640

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