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Crystal structure of restriction endonuclease EcoRII mutant R88A

Analyse Crystal structure of restriction endonuclease EcoRII mutant R88A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NA6
Type: protein
Length: 760 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.1
Source: Escherichia coli
Molecule: Restriction endonuclease EcoRII
EC: 3.1.21.4
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · resolution 2.1 · 2 distinct chains · 42% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Restriction endonuclease EcoRII (EC 3.1.21.4)	protein	365	42% helix, 15% strand	—
B	Restriction endonuclease EcoRII (EC 3.1.21.4)	protein	395	43% helix, 16% strand	—

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1144	0.78	0.80	80	empty
2	406	0.66	0.79	29	empty
3	242	0.58	0.79	31	empty
4	97	0.39	0.76	24	empty
5	58	0.30	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 2055 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

1NA6 · Crystal structure of restriction endonuclease ecorii mutant R88A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1NA6 · PDBe 1NA6

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