MolNFT v1 · #15614 · protein
Crystal structure of restriction endonuclease ecorii mutant R88A
1NA6: “Crystal structure of restriction endonuclease ecorii mutant R88A”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #15614 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1NA6
- Type
- protein
- Length
- 760 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Restriction endonuclease ecorii
- EC
- 3.1.21.4
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Restriction endonuclease ecorii (EC 3.1.21.4) | protein | 365 | 42% helix, 15% strand | — |
| B | Restriction endonuclease ecorii (EC 3.1.21.4) | protein | 395 | 43% helix, 16% strand | — |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1144 | 0.78 | 0.80 | 80 | empty |
| 2 | 406 | 0.66 | 0.79 | 29 | empty |
| 3 | 242 | 0.58 | 0.79 | 31 | empty |
| 4 | 97 | 0.39 | 0.76 | 24 | empty |
| 5 | 58 | 0.30 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2055 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 1NA6 · Crystal structure of restriction endonuclease EcoRII mutant R88A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1NA6 · PDBe 1NA6
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