Research workbench
2.3 Angstrom resolution structure of dimeric HigBA toxin-antitoxin complex from E. coli
Analyse 2.3 Angstrom resolution structure of dimeric HigBA toxin-antitoxin complex from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6KMQ
- Type
- protein
- Length
- 207 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.35
- Source
- Escherichia coli K-12
- Molecule
- mRNA interferase toxin HigB; Antitoxin HigA
- EC
- 3.1.-.-
- UniProt
- P64578, P67701
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · resolution 2.35 · 2 distinct chains · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | mRNA interferase toxin HigB (EC 3.1.-.-) | protein | 91 | 33% helix, 30% strand | P64578 |
| B | Antitoxin HigA | protein | 116 | 65% helix, 0% strand | P67701 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.35 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1530 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 6KMQ · 2.3 ångström resolution structure of dimeric higba toxin-antitoxin complex from E. COLI · the same entry in another collection · chain A against A, TM-score 1.00
- P64578 · AlphaFold monomer V2.0 prediction for mRNA interferase toxin higb (P64578) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P67701 · AlphaFold monomer V2.0 prediction for antitoxin higa (P67701) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P64578
- Every structure of UniProt P67701
- Elsewhere: RCSB PDB 6KMQ · PDBe 6KMQ · UniProt P64578 · UniProt P67701
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