MolNFT v1 · #154800 · protein
2.3 ångström resolution structure of dimeric higba toxin-antitoxin complex from E. COLI
6KMQ · MRNA interferase toxin higb: “2.3 ångström resolution structure of dimeric higba toxin-antitoxin complex from E. COLI”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #154800 on GenesisL1: 3D structure, binding…
- PDB
- 6KMQ
- Type
- protein
- Length
- 207 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MRNA interferase toxin higb; Antitoxin higa
- EC
- 3.1.-.-
- UniProt
- P64578, P67701
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MRNA interferase toxin higb (EC 3.1.-.-) | protein | 91 | 33% helix, 30% strand | P64578 |
| B | Antitoxin higa | protein | 116 | 65% helix, 0% strand | P67701 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.35 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1530 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 6KMQ · 2.3 Angstrom resolution structure of dimeric HigBA toxin-antitoxin complex from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
- P64578 · AlphaFold monomer V2.0 prediction for mRNA interferase toxin higb (P64578) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P67701 · AlphaFold monomer V2.0 prediction for antitoxin higa (P67701) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P64578
- Every structure of UniProt P67701
- Elsewhere: RCSB PDB 6KMQ · PDBe 6KMQ · UniProt P64578 · UniProt P67701
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