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The microtubule-binding domains of yeast cytoplasmic dynein in the low affinity state

Analyse The microtubule-binding domains of yeast cytoplasmic dynein in the low affinity… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6KJO
Type: protein
Length: 141 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Molecule: Dynein heavy chain, cytoplasmic
UniProt: P36022
Pockets: 4 · best druggability 0.43

Structure

solution nmr · resolution NOT · 1 distinct chain · 56% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dynein heavy chain, cytoplasmic	protein	141	56% helix, 0% strand	P36022

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.43	0.81	13	empty
2	68	0.38	0.78	15	empty
3	107	0.37	0.74	17	empty
4	53	0.28	0.74	11	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6KJO · The microtubule-binding domains of yeast cytoplasmic dynein in the low affinity state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P36022
Elsewhere: RCSB PDB 6KJO · PDBe 6KJO · UniProt P36022

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