MolNFT v1 · #154699 · protein
The microtubule-binding domains of yeast cytoplasmic dynein in the low affinity state
6KJO · Dynein heavy chain, cytoplasmic: “The microtubule-binding domains of yeast cytoplasmic dynein in the low affinity state”. Solution nmr, 4 pockets (best druggability 0.43). MolNFT v1 #154699 on GenesisL1: 3D structure, binding sites…
- PDB
- 6KJO
- Type
- protein
- Length
- 141 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dynein heavy chain, cytoplasmic
- UniProt
- P36022
- Pockets
- 4 · best druggability 0.43
Structure
solution nmr · 1 distinct chain · 56% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dynein heavy chain, cytoplasmic | protein | 141 | 56% helix, 0% strand | P36022 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.43 | 0.81 | 13 | empty |
| 2 | 68 | 0.38 | 0.78 | 15 | empty |
| 3 | 107 | 0.37 | 0.74 | 17 | empty |
| 4 | 53 | 0.28 | 0.74 | 11 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6KJO · The microtubule-binding domains of yeast cytoplasmic dynein in the low affinity state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36022
- Elsewhere: RCSB PDB 6KJO · PDBe 6KJO · UniProt P36022
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