Research workbench
AAV5 in complex with AAVR
Analyse AAV5 in complex with AAVR in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6JCS
- Type
- protein
- Length
- 613 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.18
- Source
- Adeno-associated virus - 5; Homo sapiens
- Molecule
- Capsid protein; Dyslexia-associated protein KIAA0319-like protein
- UniProt
- Q9YIJ1, Q8IZA0
- Pockets
- 7 · best druggability 0.70
Structure
electron microscopy · resolution 3.18 · 2 distinct chains · 4% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Capsid protein | protein | 516 | 4% helix, 34% strand | Q9YIJ1 |
| R | Dyslexia-associated protein KIAA0319-like protein | protein | 97 | 0% helix, 38% strand | Q8IZA0 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 762 | 0.70 | 0.76 | 81 | empty |
| 2 | 359 | 0.55 | 0.74 | 52 | empty |
| 3 | 296 | 0.54 | 0.75 | 35 | empty |
| 4 | 51 | 0.33 | 0.78 | 14 | empty |
| 5 | 84 | 0.33 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–R · 751 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9YIJ1
- Every structure of UniProt Q8IZA0
- Elsewhere: RCSB PDB 6JCS · PDBe 6JCS · UniProt Q9YIJ1 · UniProt Q8IZA0
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