MolNFT v1 · #153385 · protein

AAV5 in complex with aavr

6JCS · Capsid protein: “AAV5 in complex with aavr”. Electron microscopy, 7 pockets (best druggability 0.70). MolNFT v1 #153385 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JCS
Type: protein
Length: 613 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Capsid protein; Dyslexia-associated protein KIAA0319-like protein
UniProt: Q9YIJ1, Q8IZA0
Pockets: 7 · best druggability 0.70

Structure

electron microscopy · 2 distinct chains · 4% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Capsid protein	protein	516	4% helix, 34% strand	Q9YIJ1
R	Dyslexia-associated protein KIAA0319-like protein	protein	97	0% helix, 38% strand	Q8IZA0

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	762	0.70	0.76	81	empty
2	359	0.55	0.74	52	empty
3	296	0.54	0.75	35	empty
4	51	0.33	0.78	14	empty
5	84	0.33	0.73	16	empty

Interfaces

1 interface between chains.

A–R · 751 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

6JCS · AAV5 in complex with AAVR · the same entry in another collection · chain A against A, TM-score 1.00
Q8IZA0 · AlphaFold monomer V2.0 prediction for dyslexia-associated protein KIAA0319-like protein… · a predicted model of the same protein · chain R against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9YIJ1
Every structure of UniProt Q8IZA0
Elsewhere: RCSB PDB 6JCS · PDBe 6JCS · UniProt Q9YIJ1 · UniProt Q8IZA0

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