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Crystal Structure of the acyltransferase domain from module 8 of the salinomycin polyketide synthase

Analyse Crystal Structure of the acyltransferase domain from module 8 of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6IYR
Type: protein
Length: 423 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.05
Source: Streptomyces albus subsp. albus
Molecule: Type I modular polyketide synthase
UniProt: H1ZZT7
Ligands: PO4
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · resolution 2.05 · 1 distinct chain · 45% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Type I modular polyketide synthase	protein	423	45% helix, 16% strand	H1ZZT7

Ligands and binding sites

PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	234	0.62	0.81	31	PO4
2	76	0.42	0.80	16	empty
3	60	0.38	0.79	15	empty
4	93	0.36	0.75	21	empty

Compared structures

6IYR · Crystal structure of the acyltransferase domain from module 8 of the salinomycin… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H1ZZT7
Elsewhere: RCSB PDB 6IYR · PDBe 6IYR · UniProt H1ZZT7

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