MolNFT v1 · #152951 · protein
Crystal structure of the acyltransferase domain from module 8 of the salinomycin polyketide synthase
6IYR · Type I modular polyketide synthase: “Crystal structure of the acyltransferase domain from module 8 of the salinomycin polyketide synthase”. X-ray diffraction, 1 ligand (PO4), 4 pockets (best druggability 0.62). MolNFT v1 #152951 on…
- PDB
- 6IYR
- Type
- protein
- Length
- 423 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type I modular polyketide synthase
- UniProt
- H1ZZT7
- Ligands
- PO4
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Type I modular polyketide synthase | protein | 423 | 45% helix, 16% strand | H1ZZT7 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 234 | 0.62 | 0.81 | 31 | PO4 |
| 2 | 76 | 0.42 | 0.80 | 16 | empty |
| 3 | 60 | 0.38 | 0.79 | 15 | empty |
| 4 | 93 | 0.36 | 0.75 | 21 | empty |
Compared structures
- 6IYR · Crystal Structure of the acyltransferase domain from module 8 of the salinomycin… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H1ZZT7
- Elsewhere: RCSB PDB 6IYR · PDBe 6IYR · UniProt H1ZZT7
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