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Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of enterovirus-D68 (fusion protein)
Analyse Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HM8
- Type
- protein
- Length
- 171 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.277
- Source
- Enterovirus D68; Homo sapiens
- Molecule
- Golgi resident protein GCP60; Genome polyprotein
- EC
- 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- Q9H3P7, A0A2K9Y515
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · resolution 2.277 · 2 distinct chains · 20% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Golgi resident protein GCP60 | protein | 128 | 9% helix, 53% strand | Q9H3P7 |
| B | Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 43 | 53% helix, 19% strand | A0A2K9Y515 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.34 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1419 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6HM8 · Crystal structure of human ACBD3 gold domain in complex with 3A protein of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H3P7 · AlphaFold monomer V2.0 prediction for golgi resident protein GCP60 (Q9H3P7) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H3P7
- Every structure of UniProt A0A2K9Y515
- Elsewhere: RCSB PDB 6HM8 · PDBe 6HM8 · UniProt Q9H3P7 · UniProt A0A2K9Y515
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