MolNFT v1 · #151382 · protein

Crystal structure of human ACBD3 gold domain in complex with 3A protein of enterovirus-D68 (fusion protein)

6HM8 · Golgi resident protein GCP60: “Crystal structure of human ACBD3 gold domain in complex with 3A protein of enterovirus-D68 (fusion protein)”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #151382 on GenesisL1: 3D…

PDB: 6HM8
Type: protein
Length: 171 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Golgi resident protein GCP60; Genome polyprotein
EC: 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48
UniProt: Q9H3P7, A0A2K9Y515
Pockets: 1 · best druggability 0.34

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Golgi resident protein GCP60	protein	128	9% helix, 53% strand	Q9H3P7
B	Genome polyprotein (EC 3.4.22.29, 3.6.1.15, 3.4.22.28, 2.7.7.48)	protein	43	53% helix, 19% strand	A0A2K9Y515

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.34	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 1419 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

6HM8 · Crystal structure of human ACBD3 GOLD domain in complex with 3A protein of… · the same entry in another collection · chain A against A, TM-score 1.00
Q9H3P7 · AlphaFold monomer V2.0 prediction for golgi resident protein GCP60 (Q9H3P7) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H3P7
Every structure of UniProt A0A2K9Y515
Elsewhere: RCSB PDB 6HM8 · PDBe 6HM8 · UniProt Q9H3P7 · UniProt A0A2K9Y515

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