Research workbench
Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD ligand
Analyse Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HAZ
- Type
- protein
- Length
- 226 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.31
- Source
- Homo sapiens
- Molecule
- Probable global transcription activator SNF2L2
- EC
- 3.6.4.-
- UniProt
- P51531
- Ligands
- FX5, ZN
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · resolution 1.31 · 1 distinct chain · 65% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable global transcription activator SNF2L2 (EC 3.6.4.-) | protein | 113 | 65% helix, 2% strand | P51531 |
Ligands and binding sites
- FX5 · 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl) phenol · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 481 | 0.68 | 0.79 | 55 | FX5 |
| 2 | 68 | 0.50 | 0.84 | 16 | FX5 |
Interfaces
1 interface between chains.
- A–B · 586 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6HAZ · Crystal structure of the bromodomain of human SMARCA2 in complex with smarca-bd ligand · the same entry in another collection · chain A against A, TM-score 1.00
- P51531 · AlphaFold monomer V2.0 prediction for probable global transcription activator SNF2L2… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51531
- Elsewhere: RCSB PDB 6HAZ · PDBe 6HAZ · UniProt P51531
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.