UniProt P51531
Isoform Short of Probable global transcription activator SNF2L2 (P51531)
Isoform Short of Probable global transcription activator SNF2L2 (UniProt P51531), EC 3.6.4.-: 16 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 20 pockets. Binding sites, druggability and experiment…
- UniProt
- P51531
- Protein
- Isoform Short of Probable global transcription activator SNF2L2
- EC
- 3.6.4.-
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 20 · 4 records with a druggable one
Structures
17 records of P51531 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DAT | Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent… | solution nmr | A | — | — |
| 2DAT | Solution structure of the bromodomain of human SWI/SNF related matrix associated actin dependent… | solution nmr | A | — | — |
| 5DKC | Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe | x-ray diffraction | A | ZN, 5BW | — |
| 5DKC | Crystal structure of the bromodomain of human brm (SMARCA2) in complex with pfi-3 chemical probe | x-ray diffraction | A | — | — |
| 5DKH | Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl prope… | x-ray diffraction | A, B, C | ZN, 5C0 | — |
| 5DKH | Crystal structure of the bromodomain of human brm (SMARCA2) in complex with a hydroxyphenyl… | x-ray diffraction | A, B, C | — | — |
| 6EG2 | Crystal structure of human brm in complex with compound 16 | x-ray diffraction | A | J7J | — |
| 6EG3 | Crystal structure of human brm in complex with compound 15 | x-ray diffraction | A | J7G | — |
| 6HAX | Crystal structure of protac 2 in complex with the bromodomain of human SMARCA2 and… | x-ray diffraction | A, E | FWZ | — |
| 6HAY | Crystal structure of PROTAC 1 in complex with the bromodomain of human SMARCA2 and… | x-ray diffraction | A, E | FX8 | — |
| 6HAY | Crystal structure of protac 1 in complex with the bromodomain of human SMARCA2 and… | x-ray diffraction | A, E | FX8 | — |
| 6HAZ | Crystal structure of the bromodomain of human SMARCA2 in complex with SMARCA-BD ligand | x-ray diffraction | A, B | FX5, ZN | — |
| 6HAZ | Crystal structure of the bromodomain of human SMARCA2 in complex with smarca-bd ligand | x-ray diffraction | A, B | FX5, ZN | — |
| 7Z76 | Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and… | x-ray diffraction | D | IFJ, IOD | 1 (best 0.64) |
| 7Z77 | Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and… | x-ray diffraction | D | IFF | 1 (best 0.64) |
| 9E1K | Discovery of Potent, Highly Selective and Efficacious SMARCA2 Degraders - Compound 11 | x-ray diffraction | A, B, C | A1BF5, ZN | 6 (best 0.78) |
| P51531 | AlphaFold monomer V2.0 prediction for probable global transcription activator SNF2L2 (P51531) | predicted | A | — | 12 (best 0.75) |
Ligands
- ZN · Zinc ion · in 5 records
- FX5 · 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl) phenol · in 2 records
- FX8 · (2~{S},4~{R})-~{N}-[[2-[2-[2-[2-[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide · in 2 records
- 5BW · (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one · in 1 record
- 5C0 · (2E)-3-[(6S,9R)-4-(cyclopropylamino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-10-yl]-1-(2-hydroxyphenyl)prop-2-en-1-one · in 1 record
- A1BF5 · (12S)-4-bromo-7,7-dimethyl-9-(piperidin-4-yl)indolo[1,2-a]quinazolin-5(7H)-one · in 1 record
- FWZ · (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide · in 1 record
- IFF · (2~{S},4~{R})-~{N}-[(1~{S})-4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]butyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide · in 1 record
- IFJ · (2~{S},4~{R})-~{N}-[(1~{R})-2-[(2~{R})-1-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propan-2-yl]oxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{S})-2-[[1-(dimethylamino)cyclopropyl]carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide · in 1 record
- IOD · Iodide ion · in 1 record
- J7G · 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid · in 1 record
- J7J · N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea · in 1 record
Experiment against prediction
- 7Z76 chain D against the predicted model P51531: TM-score 0.98, RMSD 0.67 Å
- 6HAY chain E against the predicted model P51531: TM-score 0.98, RMSD 0.67 Å
- 6HAY chain E against the predicted model P51531: TM-score 0.98, RMSD 0.67 Å
- 6HAZ chain A against the predicted model P51531: TM-score 0.98, RMSD 0.72 Å
- 6HAZ chain A against the predicted model P51531: TM-score 0.98, RMSD 0.72 Å
- 6HAX chain A against the predicted model P51531: TM-score 0.97, RMSD 0.72 Å
- 7Z77 chain D against the predicted model P51531: TM-score 0.97, RMSD 0.77 Å
- 5DKC chain A against the predicted model P51531: TM-score 0.97, RMSD 0.73 Å
- 5DKC chain A against the predicted model P51531: TM-score 0.97, RMSD 0.73 Å
- 6HAY chain A against the predicted model P51531: TM-score 0.97, RMSD 0.98 Å
Elsewhere
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