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Narrow Pick Filament from Pick's disease brain

Analyse Narrow Pick Filament from Pick's disease brain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6GX5
Type: protein
Length: 282 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.2
Source: Homo sapiens
Molecule: Microtubule-associated protein tau
UniProt: P10636
Pockets: 1 · best druggability 0.53

Structure

electron microscopy · resolution 3.2 · 1 distinct chain · 0% helix, 65% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Microtubule-associated protein tau	protein	94	0% helix, 65% strand	P10636

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	140	0.53	0.81	24	empty

Interfaces

3 interfaces between chains.

A–C · 4056 Å² buried · 123 hydrogen bonds · protein-protein
A–B · 4056 Å² buried · 123 hydrogen bonds · protein-protein
B–C · 52 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6GX5 · Narrow pick filament from PICK'S disease brain · the same entry in another collection · chain A against A, TM-score 1.00
P10636 · AlphaFold monomer V2.0 prediction for microtubule-associated protein tau (P10636) · a predicted model of the same protein · chain A against A, TM-score 0.27

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10636
Elsewhere: RCSB PDB 6GX5 · PDBe 6GX5 · UniProt P10636

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